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Objective:To observe the efficacy of anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin in the treatment of severe acne.Methods:Fifty patients with severe acne were selected in the Dermatology Clinic of the Third People＇s Hospital of Hangzhou from November 2018 to July 2019. They were randomly divided into the experimental group of 25 cases and the control group of 25 cases. The experimental group was treated with anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin orally. The control group was treated with isotretinoin orally alone. Before and after treatment for 56 days, lactate score, skin cuticle hydration (SCH), transepidermal water loss (TEWL) and skin physiological indexes were measured.Results:After 56 days of treatment, the TEWL and SCH of the control group were 15.75±3.31 and 10.13±3.62, the TEWL and SCH of the experimental group were 12.17±3.61 and 28.07±3.17, respectively; the difference was statistically significant ( T was 3.610 and 12.398, P was 0.002 and 0.000, respectively). The volume and depth of cyst nodule, scar depression, skin roughness, absolute value and area of erythema in the experimental group were significantly lower than those in the control group ( T was 2.280, 1.676, 2.332, 1.508, 4.813 and 3.637; P was 0.031, 0.011, 0.027, 0.040, 0.000 and 0.001, respectively). Conclusions:Anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin has a good effect on severe acne and it can reduce the barrier damage and other adverse reactions.
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Objective To investigate the effects of continuous renal replacement therapy (CRRT) on biochemical and physiological indexes of severe acute pancreatitis (SAP) and its clinical efficacy.Methods Totally 98 patients with severe acute pancreatitis admitted in our hospital were divided into experimental group(n=49) and control group(n=49).The experimental group received CRRT and the control group did not receive.Heart rate,body temperature,blood routine,urine output,mean arterial pressure,liver function,blood biochemistry and arterial blood gas analysis before and after treatment in the two groups were measured and compared before and after treatment.Results In the experimental group,respiration,heart rate,oxygen partial pressure (PO2),carbon dioxide partial pressure (PCO2),alkali residual (BE) and pH were significantly improved at 12 h after treatment,and lasted until 36 h after treatment;the differences were statistically significant (P＜0.05).In the experimental group,blood calcium increased,creatinine,urea nitrogen and blood sugar level decreased significantly,blood potassium and blood sodium level were stable within 12 h after treatment,and the difference was statistically significant,compared with the control group (P＜0.05).In the experimental group,the alanine aminotransferase (ALT) decreased significantly after 36 h of treatment,and the difference was statistically significant(P＜0.05).There was a significant difference between the experimental group and the control group in the hematocrit (HTC) and white blood cell count (WBC) before treatment (P＜ 0.05).The platelet count (PLT) in the experimental group decreased within 12 h,and the difference was statistically significant before treatment(P＜0.05).Conclusion Compared with the conventional treatment,the therapeutic effect of CRRT on SAP is more significant.The improvement of the physiological and biochemical indexes of the patients is obvious,which is of great significance to the prognosis of the patients.
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This study was aimed to explore the effects of Shengmai(SM) injection on blood pressure (BP),heart rate (HR),electrocardiogram (ECG),and serum C-reactive protein (CRP) and NO levelin Beagle dogs with myocardial ischemia (MI).A total of 30 Beagle dogs were divided into 5 groups,which were the blank control group,model control group,SM injection low-dose group (0.80 mL· kg-1),SM injection high-dose group (3.20 mL· kg-1) and isosorbidemononitrate group (0.07 mL· kg-1).The MI model was established by the subcutaneous injection of isoprenaline hydrochloride,and the drug treatments were given at the same time.At 1 h,6 h,12 h,24 h after administration,changes of BP,HR and ECG were recorded;serum CRP and NO content were detected.The results showed that compared with the blank control group,the mean arterial pressure (MBP) was significantly decreased (P＜0.01),HR was significantly increased (P＜0.01,or P＜0.05),the ECG△ST value was significantly increased (P＜0.01) in the model group.SM injection could improve symptoms mentioned above,but the effectswereslow.SM injection had a significant antagonistic effect on the decreasing of CRP content and the increasing of NO content,compared with the model group.The difference was statistically significant (P＜0.01,or P＜0.05).It was concluded that SM injection could improve the physiological indices of Beagle dogs with MI,which might be related to the regulation of CRP and the inhibition of NO secretion.
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PURPOSE: The purpose of this study was to determine the effects of a low intensity exercise program with telephone coaching on the physical fitness and physiological index of elderly women who are receiving home visiting health program. METHODS: This study was conducted using a non-equivalent control group pretest-posttest design. The participants were 53 senior citizens. The subjects (15) in experimental group 1 performed only a low-intensity exercise program and the subjects (16) in experimental group 2 performed a low intensity exercise program with telephone coaching for 16 weeks. The low intensity exercise program consisted of muscle strength band exercise, stretching, and hand exercise using balls. RESULTS: There were statistical differences in the right grip strength (p=.030), left grip strength (p=.035), raising behind of right arm (p=.046), raising behind of left arm (p=.045), postprandial blood sugar (p=.021), body mass index (p=.029). CONCLUSION: The low intensity exercise program with telephone coaching is recommended as a physical fitness and physiological index for elderly women in a home visiting health program.
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Aged , Female , Humans , Arm , Blood Glucose , Body Mass Index , Hand , Hand Strength , House Calls , Muscle Strength , Physical Fitness , TelephoneABSTRACT
Objective To study the physiological indexes of children receiving cardiopulmonary exercise testing (CPET) in order to provide some data for establishing the normal CPET reference value in Chinese children.Methods One hundred and twenty-eight healthy children underwent the CPET with the standard scheme.All children were divided into 3 groups according to ages:3-6 years old, ＞6-10 years old and ＞ 10-14 years old.The physiological indexes of CPET were collected, including maximal oxygen uptake (VO2max/kg) , oxygen uptake at anaerobic threshold (VO2/kg@AT), maximal tolerance power (Pmax), maximal heart rate (HRmax), peak respiratory minute volume to CO2 (peak VE/VCO2), slope of respiratory minute volume to CO2 (VE/VCO2 slope), maximal tidal volume (VTmax) and the maximal minute ventilation (VEmax).The range in normal values for physiological CPET variables was recorded.Results The VO2max/kg was (31.71 ± 7.31) mL/(min · kg), (31.05 ± 5.96) mL/(min · kg), and (34.10 ±8.72) mL/(min · kg) in the 3-6 years old group, ＞6-10 years old group and ＞ 10-14 years old group of boys.The VO2/kg@AT was (28.32 ± 10.20) mL/ (min · kg), (23.13 ± 9.56) mL/(min · kg), and (22.18 ± 7.72) mL/(min · kg)in the 3-6 years old group, ＞6-10 years old group and ＞ 10-14 years old group of boys.The VO2 max/kg was (29.27 ± 4.19) mL/(min · kg), (30.67 ± 5.59) mL/ (min · kg) (29.18 ± 6.56) mL/ (min · kg) in the 3-6 years old group, ＞ 6-10 years old group and ＞ 10-14 years old group of girls.The VO2@AT was (26.64 ±9.49) mL/(min · kg) ,(20.53 ±7.66) mL/(min · kg) ,(17.83 ±6.49) mL/(min · kg)in the 3-6 years old group, ＞6-10 years old group and ＞ 10-14 years old group of girls.VO2max/kg and VO2/kg@AT did not change with age,there was no gender difference in VO2max/kg(P ＞0.05).VO2/kg@AT of boys was higher than girls in the 3-6 years old group(t =2.351 ,P =0.023).The Pmax,VEmax and VTmax increased with the growth of age(boy: F =49.436,24.290,28.958, all P ＜ 0.001;girl : F =58.287,42.990,28.802, all P ＜ 0.001), but not significant in different gender group(P ＞ 0.05).In boys peak VE/VCO2, VE/VCO2 slope and HRmax were significantly different (F =4.758,P =0.012;F =8.050, P =0.001;F =3.869, P =0.026), however these indexes were not significantly different in girls(all P ＞ 0.05).Conclusions This study provides a set of data for the most important CPET variables in Chinese children.VO2max/kg does not change with age,so it can be used as a valuable parameter in exercise ability evaluation.
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C-repeat-binding factors (CBFs) are a type of important regulon in stress-related signal transduction pathways that control plant tolerance of abiotic stress. Ammopiptanthus mongolicus is the only evergreen broadleaf shrub in the northwest desert of China. The species shows strong resistance to environmental stress, especially to cold stress. An A. mongolicus CBF1 gene (AmCBF1) was cloned and transformed into tobacco. Expression of AmCBF1 could be detected in A. mongolicus shortly after exposure to low temperature of 4°C. Analysis on ratio of electrolytic leakage, soluble sugar content, free proline content, malondialdehyde (MDA) content and peroxidase (POD) activity before and after cold treatment (4°C) for 24 h indicated AmCBF1 conferred higher cold tolerance to AmCBF1 transgenic tobacco compared with the wild type and empty vector transformed tobacco.
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PURPOSE: The purpose of this study was to compare the effectiveness for infants of antifebrile therapy using a hypothermia blanket or rectal antipyretics following open heart surgery. METHODS: This was a retrospective study and 174 infants who had open heart surgery at P University Hospital, and whose body temperature body temperature exceeded 37.2degrees C were included in the study. The assessment tool was composed of 32 items was used for assessment of fever therapy, physiological indexes and antifebrile duration. Physiological indexes included systolic blood pressure, diastolic blood pressure, heart rate, pH, PaCO2, PaO2, HCO3-, SaO2, and K+ and the antifebrile duration was minutes from having a fever until BT returned to normal levels. RESULTS: The antifebrile duration with the hypothermia blanket was shorter than with rectal antipyretics. There were significant differences in the physiological indexes with either type of antifebrile therapy, but drop in BT was greater with the hypothermia blanket than rectal antipyretics. CONCLUSION: The results of this study indicate that a hypothermia blanket is a non-invasive, non-drug and safe antifebrile therapy. Therefore, a hypothermia blanket can be applied to infants with a fever following open heart surgery.
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Humans , Infant , Antipyretics , Blood Pressure , Body Temperature , Fever , Heart , Heart Rate , Hydrogen-Ion Concentration , Hyperthermia, Induced , Hypothermia , Retrospective Studies , Thoracic Surgery , Child HealthABSTRACT
PURPOSE: The purpose of this study was to show the effect of walking exercise on physiological index, physical fitness, self-esteem. depression. and life satisfaction in institutionalized elderly women aged over 70. SAMPLE AND METHOD: Data were collected from subjects who consented to participate in this program for eight weeks from the 2nd of July to the 27th of August 2005. The subjects were divided into two groups, 26 subjects in the experimental group who had walking exercise and 30 in the control group who did not have walking exercise. The intensity of the walking exercise allowed 50-65% of the maximum heartbeat. RESULTS: The results of the experiment supported the hypothesis that the experimental group would have higher flexibility, left grip strength, sense of equilibrium, self-esteem and life satisfaction and lower depression than the control group. CONCLUSION: Walking exercise has the effect of decreasing diastolic blood pressure together with improvement in flexibility, left grip strength, sense of equilibrium, self-esteem, depression and life satisfaction for institutionalized elderly women aged over 70. According to the results presented above, walking exercise can be strongly recommended for improving the health of institutionalized elderly women.
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Aged , Female , Humans , Blood Pressure , Depression , Hand Strength , Physical Fitness , Pliability , Self Concept , WalkingABSTRACT
PURPOSE: This study was to examine the effects of foot reflexion massage on sleep disturbance, depression disorder, and the physiological index of the elderly in nursing homes. METHOD: The research design was a non-equivalent control group pretest-posttest quasi-experimental study. The subjects in this study were 50 elderly people who resided in two different nursing homes in the same region. An experimental group and a control group were organized with 25 subjects respectively, and foot reflexion massage was provided for 12 sessions, 30 minutes per session. The selected dependent variables were sleep disturbance, depression disorder, and physiological indices(blood plasma serotonin, serum cortisol), which were all measured before and after foot reflexion massage was offered. Data analysis included chi2-test, t-test, paired t-test, and ANCOVA, using the SPSS program package. RESULT: 1. The experimental group improved sleep quality more than the control group. 2. The experimental group had less depression disorder than the control group. 3. The experimental group had higher serotonin levels than the control group. CONCLUSION: It's necessary to give foot reflexion massage as a successful nursing intervention to elderly who undergo a change in sleep, and suffer from a depression disorder due to a deterioration in sleep.
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Middle Aged , Male , Humans , Female , Aged, 80 and over , Aged , Sleep Wake Disorders/blood , Serotonin/blood , Massage , Hydrocortisone/blood , Foot , Depression/bloodABSTRACT
PURPOSE: This study was to examine the effects of foot reflexion massage on sleep disturbance, depression disorder, and the physiological index of the elderly in nursing homes. METHOD: The research design was a non-equivalent control group pretest-posttest quasi-experimental study. The subjects in this study were 50 elderly people who resided in two different nursing homes in the same region. An experimental group and a control group were organized with 25 subjects respectively, and foot reflexion massage was provided for 12 sessions, 30 minutes per session. The selected dependent variables were sleep disturbance, depression disorder, and physiological indices(blood plasma serotonin, serum cortisol), which were all measured before and after foot reflexion massage was offered. Data analysis included chi2-test, t-test, paired t-test, and ANCOVA, using the SPSS program package. RESULT: 1. The experimental group improved sleep quality more than the control group. 2. The experimental group had less depression disorder than the control group. 3. The experimental group had higher serotonin levels than the control group. CONCLUSION: It's necessary to give foot reflexion massage as a successful nursing intervention to elderly who undergo a change in sleep, and suffer from a depression disorder due to a deterioration in sleep.
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Middle Aged , Male , Humans , Female , Aged, 80 and over , Aged , Sleep Wake Disorders/blood , Serotonin/blood , Massage , Hydrocortisone/blood , Foot , Depression/bloodABSTRACT
Objective By comparing the physiological index and diosgenin content of rhizome between the artificial tetraploid and the wild type diploid of Dioscorea zingiberensis, it is aimed at revealing the potential utility of polyploid breeding in medicinal D. zingiberensis. Methods Three clones of the natural diploid and the artificially induced tetraploid of D. zingiberensis were used as materials in this study. The content of SOD, PPO, and soluble sugar of leaves was determined by spectrophotometry, CAT content was measured by using the method of KMnO_4 titration. And the diosgenin content in rhizome was analyzed by HPLC. Results The tetraploid plants showed higher level of SOD, PPO, CAT, soluble sugar content in leaves, and diosgenin content in rhizome than those of the diploid origins. The diosgenin content in the three clones of tetraploid plants increased to 27% as compared to wild type. Conclusion Artificially induced tetraploid presents high content of diosgenin and great potential in stress resistance, which would be available in good seed breeding for high yield of diosgenin.